Complement Activation Selectively Potentiates the Pathogenicity of the IgG2b and IgG3 Isotypes of a High Affinity Anti-Erythrocyte Autoantibody

By generating four IgG isotype-switch variants of the high affinity 34–3C anti-erythrocyte autoantibody, and comparing them to the IgG variants of the low affinity 4C8 anti-erythrocyte autoantibody that we have previously studied, we evaluated in this study how high affinity binding to erythrocytes...

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Detalhes bibliográficos
Main Authors: da Silveira, Samareh Azeredo, Kikuchi, Shuichi, Fossati-Jimack, Liliane, Moll, Thomas, Saito, Takashi, Verbeek, J. Sjef, Botto, Marina, Walport, Mark J., Carroll, Michael, Izui, Shozo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193744/
https://ncbi.nlm.nih.gov/pubmed/11901193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20012024
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