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DNA Double-Strand Breaks: Prior to but not Sufficient in Targeting Hypermutation
The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNA double-strand breaks (DSBs). As AID is capable of deaminating deoxy-cytidine (dC) to deoxy-uracil (dU),...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193713/ https://ncbi.nlm.nih.gov/pubmed/11994423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011749 |
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