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Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.
The generation of a diverse antigen receptor repertoire is fundamental for the functionality of the adaptive immune system. While the V(D)J recombination process that generates the primary antigen receptor repertoire is understood in great detail, it is still unclear by which mechanism immunoglobuli...
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| Main Authors: | , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1087699/ https://ncbi.nlm.nih.gov/pubmed/11205324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2000.0756 |
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