Interleukin-18 Regulates Acute Graft-Versus-Host Disease by Enhancing Fas-mediated Donor T Cell Apoptosis

Interleukin (IL)-18 is a recently discovered cytokine that modulates both T helper type 1 (Th1) and Th2 responses. IL-18 is elevated during acute graft-versus-host disease (GVHD). We investigated the role of IL-18 in this disorder using a well characterized murine bone marrow transplantation (BMT) m...

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Main Authors: Reddy, Pavan, Teshima, Takanori, Kukuruga, Mark, Ordemann, Rainer, Liu, Chen, Lowler, Kathy, Ferrara, James L.M.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2001
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193680/
https://ncbi.nlm.nih.gov/pubmed/11714750
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