Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

Using a tumor model of spontaneously arising insulinomas expressing a defined tumor-associated antigen, we investigated whether tumor growth promotes cross-presentation and tolerance of tumor-specific T cells. We found that an advanced tumor burden enhanced cross-presentation of tumor-associated ant...

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Detalhes bibliográficos
Main Authors: Nguyen, Linh T., Elford, Alisha R., Murakami, Kiichi, Garza, Kristine M., Schoenberger, Stephen P., Odermatt, Bernhard, Speiser, Daniel E., Ohashi, Pamela S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193619/
https://ncbi.nlm.nih.gov/pubmed/11854356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20010032
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