Active Immunization Against the Vascular Endothelial Growth Factor Receptor flk1 Inhibits Tumor Angiogenesis and Metastasis

The vascular endothelial growth factor (VEGF) receptor fetal liver kinase 1 (flk1; VEGFR-2, KDR) is an endothelial cell–specific receptor tyrosine kinase that mediates physiological and pathological angiogenesis. We hypothesized that an active immunotherapy approach targeting flk1 may inhibit tumor...

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Bibliographic Details
Main Authors: Li, Yiwen, Wang, Mei-Nai, Li, Hongli, King, Karen D., Bassi, Rajiv, Sun, Haijun, Santiago, Angel, Hooper, Andrea T., Bohlen, Peter, Hicklin, Daniel J.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193561/
https://ncbi.nlm.nih.gov/pubmed/12070285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020072
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