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Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation
Regulation by transforming growth factor (TGF)-β plays an important role in immune homeostasis. TGF-β inhibits T cell functions by blocking both proliferation and differentiation. Here we show that TGF-β blocks Th1 differentiation by inhibiting the expression of T-bet, the apparent masterregulator o...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193549/ https://ncbi.nlm.nih.gov/pubmed/12045248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20012076 |
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