Requirement for Tyrosine Residues 315 and 319 within ζ Chain–Associated Protein 70 for T Cell Development

Engagement of the T cell antigen receptor (TCR) induces the transphosphorylation of the ζ chain–associated protein of 70,000 Mr (ZAP-70) protein tyrosine kinase (PTK) by the CD4/8 coreceptor associated Lck PTK. Phosphorylation of Tyr 493 within ZAP-70's activation loop results in the enzymatic...

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Bibliographic Details
Main Authors: Gong, Qian, Jin, Xiaohua, Akk, Antonina M., Foger, Niko, White, Mike, Gong, Guoqing, Wardenburg, Julie Bubeck, Chan, Andrew C.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193491/
https://ncbi.nlm.nih.gov/pubmed/11514606
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