Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.

Accumulating evidence indicates that the interdomain B regions of ZAP-70 and Syk play pivotal roles in the coupling of T-cell antigen receptor (TCR) stimulation to the activation of downstream signaling pathways. The interdomain B region of ZAP-70 contains at least three candidate sites of tyrosine...

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Autores principales: Williams, B L, Irvin, B J, Sutor, S L, Chini, C C, Yacyshyn, E, Bubeck Wardenburg, J, Dalton, M, Chan, A C, Abraham, R T
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171269/
https://ncbi.nlm.nih.gov/pubmed/10202147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.7.1832
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