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Interleukin (Il)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13

Expulsion of the gastrointestinal nematode Trichuris muris is mediated by a T helper (Th) 2 type response involving interleukin (IL)-4 and IL-13. Here we show that Th1 response–associated susceptibility involves prior activation of IL-18 and caspase-1 followed by IL-12 and interferon (IFN)-γ in the...

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Autors principals: Helmby, Helena, Takeda, Kiyoshi, Akira, Shizuo, Grencis, Richard K.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193471/
https://ncbi.nlm.nih.gov/pubmed/11489954
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