Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection

The cytokine interferon (IFN)-γ regulates immune clearance of parasitic, bacterial, and viral infections; however, the underlying mechanisms are poorly understood. Recently, a family of IFN-γ–induced genes has been identified that encode 48-kD GTP-binding proteins that localize to the endoplasmic re...

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Autori principali: Collazo, Carmen M., Yap, George S., Sempowski, Gregory D., Lusby, Kimberly C., Tessarollo, Lino, Woude, George F. Vande, Sher, Alan, Taylor, Gregory A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2001
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193451/
https://ncbi.nlm.nih.gov/pubmed/11457893
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