Sulfated Tyrosines Contribute to the Formation of the C5a Docking Site of the Human C5a Anaphylatoxin Receptor

The complement anaphylatoxin C5a and its seven-transmembrane segment (7TMS) receptor play an important role in host defense and in a number of inflammation-associated pathologies. The NH(2)-terminal domain of the C5a receptor (C5aR/CD88) contributes substantially to its ability to bind C5a. Here we...

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Autori principali: Farzan, Michael, Schnitzler, Christine E., Vasilieva, Natalya, Leung, Doris, Kuhn, Jens, Gerard, Craig, Gerard, Norma P., Choe, Hyeryun
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2001
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193433/
https://ncbi.nlm.nih.gov/pubmed/11342590
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