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Sialylated O-Glycans and Sulfated Tyrosines in the NH(2)-Terminal Domain of CC Chemokine Receptor 5 Contribute to High Affinity Binding of Chemokines
The chemokine receptor CCR5 plays an important role in leukocyte chemotaxis and activation, and also acts as a coreceptor for human and simian immunodeficiency viruses (HIV-1, HIV-2, and SIV). We provide evidence that CCR5 is O-glycosylated on serine 6 in the NH(2) terminus. The O-linked glycans, pa...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193526/ https://ncbi.nlm.nih.gov/pubmed/11733580 |
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