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Identification of a Crucial Energetic Footprint on the α1 Helix of Human Histocompatibility Leukocyte Antigen (Hla)-A2 That Provides Functional Interactions for Recognition by Tax Peptide/Hla-A2–Specific T Cell Receptors

Structural studies have shown that class I major histocompatibility complex (MHC)-restricted peptide-specific T cell receptor (TCR)-α/βs make multiple contacts with the α1 and α2 helices of the MHC, but it is unclear which or how many of these interactions contribute to functional binding. We have a...

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Main Authors: Baker, Brian M., Turner, Richard V., Gagnon, Susan J., Wiley, Don C., Biddison, William E.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193388/
https://ncbi.nlm.nih.gov/pubmed/11238586
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