Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as(2)O(3)-Induced Pml or Pml/Retinoic Acid Receptor α Degradation

Promyelocytic leukemia (PML) is the organizer of nuclear matrix domains, PML nuclear bodies (NBs), with a proposed role in apoptosis control. In acute promyelocytic leukemia, PML/retinoic acid receptor (RAR) α expression disrupts NBs, but therapies such as retinoic acid or arsenic trioxide (As(2)O(3...

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Autori principali: Lallemand-Breitenbach, Valérie, Zhu, Jun, Puvion, Francine, Koken, Marcel, Honoré, Nicole, Doubeikovsky, Alexandre, Duprez, Estelle, Pandolfi, Pier Paolo, Puvion, Edmond, Freemont, Paul, de Thé, Hugues
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2001
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193303/
https://ncbi.nlm.nih.gov/pubmed/11413191
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