Immunologic Self-Tolerance Maintained by Cd25(+)Cd4(+)Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key role in T cell–mediated dominant immunologic self-tolerance. In vivo blockade of CTLA-4 for a limited period in normal mice leads to spontaneous development of chronic organ-specific autoimmune diseases, which ar...

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Autors principals: Takahashi, Takeshi, Tagami, Tomoyuki, Yamazaki, Sayuri, Uede, Toshimitsu, Shimizu, Jun, Sakaguchi, Noriko, Mak, Tak W., Sakaguchi, Shimon
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2000
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193248/
https://ncbi.nlm.nih.gov/pubmed/10899917
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