Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

Leukocyte recruitment to target tissue is initiated by weak rolling attachments to vessel wall ligands followed by firm integrin-dependent arrest triggered by endothelial chemokines. We show here that immobilized chemokines can augment not only arrest but also earlier integrin-mediated capture (teth...

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Main Authors: Grabovsky, Valentin, Feigelson, Sara, Chen, Chun, Bleijs, Diederik A., Peled, Amnon, Cinamon, Guy, Baleux, Francoise, Arenzana-Seisdedos, Frenando, Lapidot, Tsvee, van Kooyk, Yvette, Lobb, Roy R., Alon, Ronen
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2000
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193239/
https://ncbi.nlm.nih.gov/pubmed/10952719
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