Atypical PKC-ζ regulates SDF-1–mediated migration and development of human CD34(+) progenitor cells

The chemokine stromal cell–derived factor–1 (SDF-1) and its receptor, CXCR4, play a major role in migration, retention, and development of hematopoietic progenitors in the bone marrow. We report the direct involvement of atypical PKC-ζ in SDF-1 signaling in immature human CD34(+)-enriched cells and...

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Autores principales: Petit, Isabelle, Goichberg, Polina, Spiegel, Asaf, Peled, Amnon, Brodie, Chaya, Seger, Rony, Nagler, Arnon, Alon, Ronen, Lapidot, Tsvee
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC539190/
https://ncbi.nlm.nih.gov/pubmed/15630457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200521773
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