Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

The essential upstream steps in granzyme B–mediated apoptosis remain undefined. Herein, we show that granzyme B triggers the mitochondrial apoptotic pathway through direct cleavage of Bid; however, cleavage of procaspases was stalled when mitochondrial disruption was blocked by Bcl-2. The sensitivit...

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Hauptverfasser: Sutton, Vivien R., Davis, Joanne E., Cancilla, Michael, Johnstone, Ricky W., Ruefli, Astrid A., Sedelies, Karin, Browne, Kylie A., Trapani, Joseph A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2000
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193191/
https://ncbi.nlm.nih.gov/pubmed/11085743
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