Secondary Rearrangements and Hypermutation Generate Sufficient B Cell Diversity to Mount Protective Antiviral Immunoglobulin Responses

Variable (V) region gene replacement was recently implicated in B cell repertoire diversification, but the contribution of this mechanism to antibody responses is still unknown. To investigate the role of V gene replacements in the generation of antigen-specific antibodies, we analyzed antiviral imm...

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Bibliografiske detaljer
Main Authors: López-Macías, Constantino, Kalinke, Ulrich, Cascalho, Marilia, Wabl, Matthias, Hengartner, Hans, Zinkernagel, Rolf M., Lamarre, Alain
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1999
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193076/
https://ncbi.nlm.nih.gov/pubmed/10359583
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