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Positive and negative selection invoke distinct signaling pathways

During T cell development, interaction of the T cell receptor (TCR) with cognate ligands in the thymus may result in either maturation (positive selection) or death (negative selection). The intracellular pathways that control these opposed outcomes are not well characterized. We have generated mice...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1996
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192689/
https://ncbi.nlm.nih.gov/pubmed/8691153
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