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Breaking self-tolerance in nonobese diabetic mice
Unresponsiveness to self is maintained through two mechanisms of immune regulation: thymic-negative selection and peripheral tolerance. Although thymic-negative selection is a major mechanism to eliminate self-reactive T cells, normal mice have readily detectable populations of T cells reactive to s...
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| Formato: | Artigo |
|---|---|
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2192523/ https://ncbi.nlm.nih.gov/pubmed/8666923 |
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