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Expression of diabetes-associated genes by dendritic cells and CD4 T-cells drives the loss of tolerance in nonobese diabetic mice

In humans and non-obese diabetic (NOD) mice, defects in immune tolerance result in the spontaneous development of type-1-diabetes. Recent studies have ascribed a breakdown in tolerance to dysfunction in regulatory T-cells (Tregs) that is secondary to reduced IL-2 production by T-cells having the NOD...

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書誌詳細
主要な著者: Hamilton-Williams, Emma E., Martinez, Xavier, Clark, Jan, Howlett, Sarah, Hunter, Kara M., Rainbow, Daniel B, Wen, Li, Shlomchik, Mark J., Katz, Jonathan D., Beilhack, Georg F., Wicker, Linda S., Sherman, Linda A.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733871/
https://ncbi.nlm.nih.gov/pubmed/19592648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900428
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