Expression of diabetes-associated genes by dendritic cells and CD4 T-cells drives the loss of tolerance in nonobese diabetic mice

In humans and non-obese diabetic (NOD) mice, defects in immune tolerance result in the spontaneous development of type-1-diabetes. Recent studies have ascribed a breakdown in tolerance to dysfunction in regulatory T-cells (Tregs) that is secondary to reduced IL-2 production by T-cells having the NOD...

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Detalhes bibliográficos
Main Authors: Hamilton-Williams, Emma E., Martinez, Xavier, Clark, Jan, Howlett, Sarah, Hunter, Kara M., Rainbow, Daniel B, Wen, Li, Shlomchik, Mark J., Katz, Jonathan D., Beilhack, Georg F., Wicker, Linda S., Sherman, Linda A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733871/
https://ncbi.nlm.nih.gov/pubmed/19592648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900428
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