Synergism of Xist Rna, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation

Xist RNA expression, methylation of CpG islands, and hypoacetylation of histone H4 are distinguishing features of inactive X chromatin. Here, we show that these silencing mechanisms act synergistically to maintain the inactive state. Xist RNA has been shown to be essential for initiation of X inacti...

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Main Authors: Csankovszki, Györgyi, Nagy, András, Jaenisch, Rudolf
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2001
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192370/
https://ncbi.nlm.nih.gov/pubmed/11352938
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