A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

The β-chemokine receptor CCR5 is considered to be an attractive target for inhibition of macrophage-tropic (CCR5-using or R5) HIV-1 replication because individuals having a nonfunctional receptor (a homozygous 32-bp deletion in the CCR5 coding region) are apparently normal but resistant to infection...

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Detalhes bibliográficos
Main Authors: Baba, Masanori, Nishimura, Osamu, Kanzaki, Naoyuki, Okamoto, Mika, Sawada, Hidekazu, Iizawa, Yuji, Shiraishi, Mitsuru, Aramaki, Yoshio, Okonogi, Kenji, Ogawa, Yasuaki, Meguro, Kanji, Fujino, Masahiko
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21923/
https://ncbi.nlm.nih.gov/pubmed/10318947
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