Selection of functional T cell receptor mutants from a yeast surface-display library

The heterodimeric αβ T cell receptor (TCR) for antigen is the key determinant of T cell specificity. The structure of the TCR is very similar to that of antibodies, but the engineering of TCRs by directed evolution with combinatorial display libraries has not been accomplished to date. Here, we repo...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Kieke, Michele C., Shusta, Eric V., Boder, Eric T., Teyton, Luc, Wittrup, K. Dane, Kranz, David M.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1999
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10318939/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.10.5651
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