Selection of functional T cell receptor mutants from a yeast surface-display library

The heterodimeric αβ T cell receptor (TCR) for antigen is the key determinant of T cell specificity. The structure of the TCR is very similar to that of antibodies, but the engineering of TCRs by directed evolution with combinatorial display libraries has not been accomplished to date. Here, we repo...

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Bibliografiske detaljer
Main Authors: Kieke, Michele C., Shusta, Eric V., Boder, Eric T., Teyton, Luc, Wittrup, K. Dane, Kranz, David M.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21915/
https://ncbi.nlm.nih.gov/pubmed/10318939
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