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Selection of functional T cell receptor mutants from a yeast surface-display library

The heterodimeric αβ T cell receptor (TCR) for antigen is the key determinant of T cell specificity. The structure of the TCR is very similar to that of antibodies, but the engineering of TCRs by directed evolution with combinatorial display libraries has not been accomplished to date. Here, we repo...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Kieke, Michele C., Shusta, Eric V., Boder, Eric T., Teyton, Luc, Wittrup, K. Dane, Kranz, David M.
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 1999
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC21915/
https://ncbi.nlm.nih.gov/pubmed/10318939
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