Selection of functional T cell receptor mutants from a yeast surface-display library
The heterodimeric αβ T cell receptor (TCR) for antigen is the key determinant of T cell specificity. The structure of the TCR is very similar to that of antibodies, but the engineering of TCRs by directed evolution with combinatorial display libraries has not been accomplished to date. Here, we repo...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1999
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10318939/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.10.5651 |
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