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The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn
Fas is a cell surface protein of the tumor necrosis factor receptor, nerve growth factor receptor, CD40 family, and is involved in the control of lymphocyte apoptosis. A mutation in the Fas gene in MRL/lpr mice results in massive lymphoproliferation (lpr) and accelerated autoimmunity. To further stu...
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| Format: | Artigo |
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| Language: | Inglês |
| Published: |
The Rockefeller University Press
1993
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2191101/ https://ncbi.nlm.nih.gov/pubmed/7688033 |
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