Reduced galactosyltransferase mRNA levels are associated with the agalactosyl IgG found in arthritis-prone MRL-lpr/lpr strain mice.

MRL-lpr/lpr strain mice have defectively glycosylated IgG. This may be related to the rheumatoid arthritis (RA)-like disease that occurs in these mice, because a similar glycosylation defect is seen in human subjects with RA. Whilst it is known that this defect is associated with reduced activity of...

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Bibliographic Details
Main Authors: Jeddi, P A, Lund, T, Bodman, K B, Sumar, N, Lydyard, P M, Pouncey, L, Heath, L S, Kidd, V J, Delves, P J
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1415030/
https://ncbi.nlm.nih.gov/pubmed/7835974
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