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Necrotic Death Pathway in FAS Receptor Signaling

A caspase 8–deficient subline (JB6) of human Jurkat cells can be killed by the oligomerization of Fas-associated protein with death domain (FADD). This cell death process is not accompanied by caspase activation, but by necrotic morphological changes. Here, we show that the death effector domain of...

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Detalhes bibliográficos
Main Authors: Matsumura, Hirotaka, Shimizu, Yusuke, Ohsawa, Yoshiyuki, Kawahara, Atsuo, Uchiyama, Yasuo, Nagata, Shigekazu
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190580/
https://ncbi.nlm.nih.gov/pubmed/11121439
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