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Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells

In mitotic cells, an error in chromosome segregation occurs when a chromosome is left near the spindle equator after anaphase onset (lagging chromosome). In PtK1 cells, we found 1.16% of untreated anaphase cells exhibiting lagging chromosomes at the spindle equator, and this percentage was enhanced...

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Detalhes bibliográficos
Main Authors: Cimini, Daniela, Howell, Bonnie, Maddox, Paul, Khodjakov, Alexey, Degrassi, Francesca, Salmon, E.D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190575/
https://ncbi.nlm.nih.gov/pubmed/11331303
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