The stimulatory action of tolbutamide on Ca(2+)-dependent exocytosis in pancreatic β cells is mediated by a 65-kDa mdr-like P-glycoprotein

Intracellular application of the sulfonylurea tolbutamide during whole-cell patch-clamp recordings stimulated exocytosis >5-fold when applied at a cytoplasmic Ca(2+) concentration of 0.17 μM. This effect was not detectable in the complete absence of cytoplasmic Ca(2+) and when exocytosis was elic...

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Autori principali: Barg, Sebastian, Renström, Erik, Berggren, Per-Olof, Bertorello, Alejandro, Bokvist, Krister, Braun, Matthias, Eliasson, Lena, Holmes, William E., Köhler, Martin, Rorsman, Patrik, Thévenod, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1999
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC21895/
https://ncbi.nlm.nih.gov/pubmed/10318919
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