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The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I-mediated conversion to membranolytic products

The mechanism of toxicity for cytolytic lymphocytes of Leu-Leu-OMe and related dipeptide derivatives was examined. Selective inhibition of dipeptidyl peptidase I (DPPI), a lysosomal thiol protease highly enriched in cytotoxic lymphocytes, prevented all natural killer (NK) toxic effects of such agent...

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Bibliografiske detaljer
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1990
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2188150/
https://ncbi.nlm.nih.gov/pubmed/1972727
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