Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)

Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the channel is activated by capsaicin. In addition, studies have suggested that phosphorylation by PKC might directly gate the...

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Main Authors: Bhave, Gautam, Hu, Hui-Juan, Glauner, Kathi S., Zhu, Weiguo, Wang, Haibin, Brasier, D. J., Oxford, Gerry S., Gereau, Robert W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC218783/
https://ncbi.nlm.nih.gov/pubmed/14523239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2032100100
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