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Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain
The highly selective cytotoxicity of site-directed ricin A chain conjugates can be potentiated by membrane-active carboxylic ionophores. The combined use of the two agents results in much faster inactivation of ribosomes and subsequent cell death and lysis. The potency of A chain cytotoxins is corre...
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| Format: | Artigo |
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| Language: | Inglês |
| Published: |
The Rockefeller University Press
1984
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2187464/ https://ncbi.nlm.nih.gov/pubmed/6090575 |
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