Bivalency as a principle for proteasome inhibition

The proteasome, a multicatalytic protease, is known to degrade unfolded polypeptides with low specificity in substrate selection and cleavage pattern. This lack of well-defined substrate specificities makes the design of peptide-based highly selective inhibitors extremely difficult. However, the x-r...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Loidl, Günther, Groll, Michael, Musiol, Hans-Jürgen, Huber, Robert, Moroder, Luis
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1999
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21874/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10318898/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.10.5418
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