Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin
Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thrombin. Structural data suggest that the side chain of Arg-35 projects toward the active site pocket of th...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC218711/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14523228/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2135346100 |
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