HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

The RING finger proteins HdmX and Hdm2 share significant structural and functional similarity. Hdm2 is a member of the RING finger family of ubiquitin-protein ligases E3 and targets the tumor suppressor protein p53 for degradation. Although HdmX also binds to p53, HdmX does not induce p53 degradatio...

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Detaylı Bibliyografya
Asıl Yazarlar: Linares, Laëtitia K., Hengstermann, Arnd, Ciechanover, Aaron, Müller, Stefan, Scheffner, Martin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2003
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC218704/
https://ncbi.nlm.nih.gov/pubmed/14507994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2030930100
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