HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
The RING finger proteins HdmX and Hdm2 share significant structural and functional similarity. Hdm2 is a member of the RING finger family of ubiquitin-protein ligases E3 and targets the tumor suppressor protein p53 for degradation. Although HdmX also binds to p53, HdmX does not induce p53 degradatio...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2003
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC218704/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14507994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2030930100 |
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