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Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3

Activation of the alternative pathway of complement commences with the formation of an initial fluid-phase C3 convertase. Treatment of C3 with the nucleophilic reagent methylamine has previously been shown to result in the cleavage of an intramolecular thioester bond and to induce C3b-like propertie...

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Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1981
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2186450/
https://ncbi.nlm.nih.gov/pubmed/6912277
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