Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals

In paroxysmal nocturnal hemoglobinuria (PNH), acquired somatic mutations in the PIG-A gene give rise to clonal populations of red blood cells unable to express proteins linked to the membrane by a glycosylphosphatidylinositol anchor. These proteins include the complement inhibitors CD55 and CD59, an...

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Bibliographic Details
Main Authors: Araten, David J., Nafa, Khedoudja, Pakdeesuwan, Kriangsak, Luzzatto, Lucio
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC21843/
https://ncbi.nlm.nih.gov/pubmed/10220445
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