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Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal

By binding specific RNA transcripts, the Sex-lethal protein (SXL) governs sexual differentiation and dosage compensation in Drosophila melanogaster. To investigate the basis for RNA binding specificity, we determined the crystal structure of the tandem RNA recognition motifs (RRMs) of SXL. Both RRMs...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Crowder, Scott M., Kanaar, Roland, Rio, Donald C., Alber, Tom
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21787/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10220389/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.9.4892
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