Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal

By binding specific RNA transcripts, the Sex-lethal protein (SXL) governs sexual differentiation and dosage compensation in Drosophila melanogaster. To investigate the basis for RNA binding specificity, we determined the crystal structure of the tandem RNA recognition motifs (RRMs) of SXL. Both RRMs...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Crowder, Scott M., Kanaar, Roland, Rio, Donald C., Alber, Tom
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21787/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10220389/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.9.4892
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