Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex

Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an inherited disorder caused by mutations in the genes encoding the TJ proteins claudin-16 (CLDN16) and CLDN19; however, the mec...

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Detalhes bibliográficos
Main Authors: Hou, Jianghui, Renigunta, Aparna, Konrad, Martin, Gomes, Antonio S., Schneeberger, Eveline E., Paul, David L., Waldegger, Siegfried, Goodenough, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176193/
https://ncbi.nlm.nih.gov/pubmed/18188451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33970
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