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PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice
Transgenic mice expressing HCV core protein develop hepatic steatosis and hepatocellular carcinoma (HCC), but the mechanism underlying this process remains unclear. Because PPARα is a central regulator of triglyceride homeostasis and mediates hepatocarcinogenesis in rodents, we determined whether PP...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2176192/ https://ncbi.nlm.nih.gov/pubmed/18188449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33594 |
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