PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice

Transgenic mice expressing HCV core protein develop hepatic steatosis and hepatocellular carcinoma (HCC), but the mechanism underlying this process remains unclear. Because PPARα is a central regulator of triglyceride homeostasis and mediates hepatocarcinogenesis in rodents, we determined whether PP...

Full description

Saved in:
Bibliographic Details
Main Authors: Tanaka, Naoki, Moriya, Kyoji, Kiyosawa, Kendo, Koike, Kazuhiko, Gonzalez, Frank J., Aoyama, Toshifumi
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176192/
https://ncbi.nlm.nih.gov/pubmed/18188449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33594
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items