PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice

Transgenic mice expressing HCV core protein develop hepatic steatosis and hepatocellular carcinoma (HCC), but the mechanism underlying this process remains unclear. Because PPARα is a central regulator of triglyceride homeostasis and mediates hepatocarcinogenesis in rodents, we determined whether PP...

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Detalhes bibliográficos
Main Authors: Tanaka, Naoki, Moriya, Kyoji, Kiyosawa, Kendo, Koike, Kazuhiko, Gonzalez, Frank J., Aoyama, Toshifumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176192/
https://ncbi.nlm.nih.gov/pubmed/18188449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33594
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