PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice

Transgenic mice expressing HCV core protein develop hepatic steatosis and hepatocellular carcinoma (HCC), but the mechanism underlying this process remains unclear. Because PPARα is a central regulator of triglyceride homeostasis and mediates hepatocarcinogenesis in rodents, we determined whether PP...

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Bibliographische Detailangaben
Hauptverfasser: Tanaka, Naoki, Moriya, Kyoji, Kiyosawa, Kendo, Koike, Kazuhiko, Gonzalez, Frank J., Aoyama, Toshifumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176192/
https://ncbi.nlm.nih.gov/pubmed/18188449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33594
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