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Interleukin-5 Priming of Human Eosinophils Alters Siglec-8–Mediated Apoptosis Pathways
Previously, we have identified the sequential activation of reactive oxygen species (ROS), mitochondria, and caspase-3, -8, and -9, in Siglec-8–mediated eosinophil apoptosis. Cytokine priming, which normally prolongs eosinophil survival, paradoxically potentiated this proapoptotic effect. The mechan...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Thoracic Society
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2176128/ https://ncbi.nlm.nih.gov/pubmed/17690326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0154OC |
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