Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

BACKGROUND: Siglec-F is a glycan binding protein selectively expressed on mouse eosinophils. Its engagement induces apoptosis, suggesting a pathway for ameliorating eosinophilia in asthma and other eosinophil-associated diseases. Siglec-F recognizes sialylated, sulfated glycans in glycan binding ass...

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Bibliographic Details
Published in:J Allergy Clin Immunol
Main Authors: Kiwamoto, Takumi, Katoh, Toshihiko, Evans, Christopher M., Janssen, William J., Brummet, Mary E., Hudson, Sherry A., Zhu, Zhou, Tiemeyer, Michael, Bochner, Bruce S.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433759/
https://ncbi.nlm.nih.gov/pubmed/25497369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.10.027
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