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Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis
BACKGROUND: Siglec-F is a glycan binding protein selectively expressed on mouse eosinophils. Its engagement induces apoptosis, suggesting a pathway for ameliorating eosinophilia in asthma and other eosinophil-associated diseases. Siglec-F recognizes sialylated, sulfated glycans in glycan binding ass...
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| Udgivet i: | J Allergy Clin Immunol |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4433759/ https://ncbi.nlm.nih.gov/pubmed/25497369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.10.027 |
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