Pharmacological characterization of acetylcholine-stimulated [35S]-GTP gamma S binding mediated by human muscarinic m1-m4 receptors: antagonist studies.

1. We have used dose-ratio analysis to estimate functionally the affinity constants (pKb) and Schild slope factors of a range of selective or atypical antagonists at human muscarinic m1-m4 receptors. 2. The functional response was the stimulation by acetylcholine of [35S]-GTP gamma S binding to memb...

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Detaylı Bibliyografya
Asıl Yazarlar: Lazareno, S., Birdsall, N. J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 1993
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175752/
https://ncbi.nlm.nih.gov/pubmed/8401923
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